Figure 2.

Anticipatory ACC activation associated with amygdala and mid-insula responses modulated by uncertainty. Voxelwise regressions (P < 0.05, corrected) indicated relationships between anticipatory activation in circled ACC regions and activation in the right amygdala (A), left amygdala (B), right mid-insula (C), and left mid-insula (D) areas circled in Figure 1 that were modulated by uncertainty. Plots illustrate that individual differences in anticipatory ACC activity were inversely associated with mid-insula and amygdala responses, such that individuals with greater ACC activation to the uncertain cue than the certain aversive cue showed the smallest uncertainty-related enhancement of mid-insula and amygdala activation to aversive pictures. U = uncertain condition; C = certain condition.