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. 1997 Dec 9;94(25):13713–13718. doi: 10.1073/pnas.94.25.13713

Figure 4.

Figure 4

Both the axis inducing and neural crest inducing activities of Xwnt-3a are antagonized by GSK-3β. (a) GSK-3β partially inhibits axis rescue by Xwnt-3a. Partial rescue is observed in UV-treated embryos (DAI 0.1) injected with Xwnt-8 RNA (DAI 3.9) or Xwnt-3a RNA (DAI 2.6); rescue is inhibited when Xwnt-8 plus GSK-3β RNAs (DAI 1) or Xwnt-3a plus GSK-3β RNAs (DAI 1.2) are coinjected. (b) GSK-3β inhibits neural crest induction by Xwnt-3a. Northern blot from animal explants injected with Xwnt-3a or Xwnt-8 RNAs plus noggin RNA, with (+GSK-3β) or without GSK-3β RNA. Coinjection of GSK-3β and noggin RNAs leads to the same repertoire of gene expression as noggin RNA alone (data not shown). DAI, dorsoanterior index (30).