Expression of dorsal and ventral neural genes in animal explants injected with noggin RNA, Xwnt-3a RNA, or a combination of both. Animal explants coexpressing noggin and Xwnt-3a activate a broad range of dorsally expressed genes (Krox-20, slug, wnt-1, and pax-3) but failed to activate ventrally expressed genes (shh and FKH-1).