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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Semin Immunopathol. 2009 Dec 13;32(1):33–42. doi: 10.1007/s00281-009-0185-0

Figure 1. Alternative models of IL-17RC downstream signaling events.

Figure 1

Two possible ways in which IL-17RC may participate in signaling are depicted. A. Upon ligand binding, IL-17RC recruits a novel signaling intermediate, resulting in the following downstream effector functions: (1) possible post-translational modifications on Act1, (2) recruitment of TRAF6, and/or (3) activation of novel effector signaling pathways. These events result in the creating of an appropriate molecular scaffold necessary for IL-17-dependent signaling. B. Upon ligand binding, IL-17RC recruits Act1 through a homotypic SEFIR docking interaction. IL-17RC-bound Act1 oligomerizes with IL-17RA-bound Act1, resulting in an effective recruitment of intermediates for efficient IL-17-dependent signal transduction.

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