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. Author manuscript; available in PMC: 2010 Sep 11.
Published in final edited form as: Nature. 2010 Jan 31;464(7286):232–236. doi: 10.1038/nature08784

Figure 1. Architecture of the PFV intasome.

Figure 1

a, Views along (left) and perpendicular (right) to the crystallographic two-fold axis. The inner subunits of the IN tetramer, engaged with viral DNA, are blue and green; outer IN chains are yellow. The reactive and non-transferred DNA strands are magenta and orange, respectively. Side chains of Asp128, Asp185 and Glu221 active site residues are red sticks; gray spheres are Zn atoms. Locations of the canonical IN domains (NTD, CCD and CTD) are indicated; b, inner (green) IN chain with domains and linkers indicated. The orientation is the same as in the right panel of a.