. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Pediatr Cardiol. 2009 Dec 29;31(3):414–421. doi: 10.1007/s00246-009-9616-x

Table 2.

Transcription factors and their downstream targets involved in heart valve development (see text for details and references)

Gene	Known downstream targets expressed in valves	Function in valve progenitor/mesenchymal cell development
Twist1	Periostin, Tbx20, Col2a1, cdh11	Proliferation/migration/ECM organization/collagen production
Tbx20	N-myc, Tbx2, Isl1	Proliferation/differentiation
Msx1	None identified	EMT/cushion formation
Msx2	None identified	EMT/cushion formation
NFATc1	NFATc1, DSCR1, CtsK	Cushion endothelial cell proliferation/valve ECM remodeling
Sox9	Aggrecan, Col2a1, Col11a2, Hapln1	Proliferation/differentiation
Scx	Col14a1, tenomodulin	Differentiation/ECM organization