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. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: Annu Rev Biochem. 2009;78:1017–1040. doi: 10.1146/annurev.biochem.78.072407.103859

Figure 4.

Figure 4

Expression of cholesterol 24-hydroxylase in the brain. (a) Wild-type mouse cortical section stained with monoclonal antibody 1A7 showing expression of the enzyme (green stain) in pyramidal neurons of layers II/III, V, and VI. (b) Section from cortex of cholesterol 24-hydroxylase knockout mouse stained with monoclonal antibody 1A7. (c) Three-dimensional reconstruction of cholesterol 24-hydroxylase staining and cytochrome P450 reductase staining showing colocalization of the two proteins in the dendritic endoplasmic reticulum of a cultured primary cortical neuron. Reprinted with permission from Reference 62.