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. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: Annu Rev Biochem. 2009;78:1017–1040. doi: 10.1146/annurev.biochem.78.072407.103859

Figure 7.

Figure 7

Hippocampal long-term potentiation (LTP) in wild-type and cholesterol 24-hydroxylase knockout mice. (a) Baseline responses to monophasic stimulation were recorded for 20 min in slices from 5-week-old animals of the indicated genotype, and then the tissue was subjected to high-frequency stimulation, θ-burst (arrow). Subsequent responses to monophasic stimulation were strengthened in wild-type slices and less so in knockout slices. Insets show recorded potentials before (dashed lines) and 55 min after (solid lines) tetanization. (b) Effect of inhibition of cholesterol synthesis with a statin on hippocampal LTP. Redrawn and reprinted with permission from Reference 79. Abbreviations: fEPSP slope, slope of extracellularly recorded (field) excitatory postsynaptic potentials; +/+, wild type for cholesterol 24-hydroxylase; −/−, homozygous for cholesterol 24-hydroxylase mutation.