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. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: Annu Rev Biochem. 2009;78:1017–1040. doi: 10.1146/annurev.biochem.78.072407.103859

Figure 8.

Figure 8

Restoration of hippocampal long-term potentiation by geranylgeraniol treatment of slices from cholesterol 24-hydroxylase knockout mice (a) and those from wild-type mice treated with a statin (b). Data in (a) redrawn and reprinted with permission from Reference 79. Abbreviations: fEPSP slope, slope of extracellularly recorded (field) excitatory postsynaptic potentials; +/+, wild type for cholesterol 24-hydroxylase; −/−, homozygous for cholesterol 24-hydroxylase mutation; arrow, time of θ-burst stimulation; NS, not significant.