Table 1.
Metabolic Parameter | 3/7/2000 | 4/3/2001 | 2/3/2003 | 7/22/2004 | 1/27/2005 | 7/11/2006 | 2/22/2007 |
---|---|---|---|---|---|---|---|
Atorvastatin begun | Pravastin/fenofibrate begun | Pravastin/fenofibrate increased | |||||
Body Weight (kg) | 77.6 | 86.6 | 86.1 | 98.8 | 105.2 | 101.2 | 102.5 |
Body Mass Index (kg/m2) | 23.2 | 25.8 | 25.7 | 29.5 | 31.4 | 30.2 | 30.6 |
Heart Rate (beats/minute) | 68 | 84 | 82 | 72 | 72 | 66 | 74 |
Blood Pressure (mm Hg) | 130/70 | 108/80 | 130/90 | 132/88 | 118/74 | 120/82 | 106/70 |
Antiretroviral Regimen | Indinavir Lamivudine Zidovudine |
Nevirapine Abacavir Stavudine |
Nevirapine Abacavir Stavudine Tenofovir |
Fosamprenavir Ritonavir Abacavir Lamivudine Didanosine |
Fosamprenavir Ritonavir Abacavir Lamivudine Didanosine |
Fosamprenavir Ritonavir Abacavir Emtricitabine Didanosine |
Didanosine Epzicom Abacavir Emtricitabine Didanosine |
CD4 Cell Count (cells/mm3) | 493 | 672 | 735 | 1285 | 794 | 787 | 938 |
HIV RNA Level (copies/mL) | 36811 | <75 | 4353 | <75 | <75 | 2025 | 993 |
Fasting Glucose (mg/dL) | 90 | 90 | 91 | 81 | 119 | 127 | 93 |
Total Cholesterol (mg/dL) | 180 | 201 | 126 | 220 | 244 | 142 | 188 |
LDL (mg/dL) | NR | Not calculated* | 39 | Not calculated* | Not calculated* | 53 | 117 |
Triglycerides (mg/dL) | 165 | 500 | 298 | 820 | 1501 | 258 | 174 |
HIV=human immunodeficiency virus; HDL=high density lipoprotein; LDL=low-density lipoprotein; NR=not reported
LDL is unable to be calculated when serum triglyceride level exceeds 400 mg/dL.