Table 1.
Clinical variables and DJ-1 levels in MDS patients
| Diagnosis | Age, y | Sex | Karyotype | IPSS | Marrow cellularity | Marrow blasts, % | DJ-1 expression | p53 expression | DJ-1/p53 ratio | Transplant |
|---|---|---|---|---|---|---|---|---|---|---|
| RA | 65 | F | n | 0.5 | Hyper | 3 | 0.927 | 1.172 | 0.791 | No |
| RA | 62 | M | −y | 0.5 | Hyper | 4 | 0.988 | 0.704 | 1.403 | No |
| RA | 73 | F | n | 0.5 | Hyper | 2 | 0.876 | 0.921 | 0.951 | No |
| RA | 59 | F | n | 0.5 | Normal | 3 | 0.907 | 0.998 | 0.909 | Yes |
| RA | 58 | F | n | 0.5 | Normal | 2 | 0.957 | 0.974 | 0.982 | No |
| RA | 69 | F | n | 0.5 | Hyper | 3 | 1.061 | 1.017 | 1.044 | No |
| RA | 51 | M | n | 0.5 | Hypo | 4 | 0.975 | 0.98 | 0.995 | No |
| RA | 61 | F | n | 0.5 | Normal | 2 | 1.003 | 0.983 | 1.020 | No |
| RA | 57 | M | +9, +11 | 1 | Normal | 3 | 0.955 | 0.912 | 1.047 | No |
| RA | 76 | M | +5, +9, −6 | 1.5 | Hyper | 2 | 1.03 | 1.079 | 0.955 | No |
| RA | 78 | M | n | 0.5 | Normal | 4 | 1.03 | 0.973 | 1.058 | No |
| RA | 56 | F | n | 0.5 | Normal | 2 | 1.025 | 0.992 | 1.033 | No |
| RA | 79 | M | n | 0.5 | Hypo | 4 | 1.03 | 0.998 | 1.032 | No |
| RA | 56 | M | n | 0.5 | Normal | 4 | 0.87 | 1.056 | 0.824 | No |
| RA | 68 | F | n | 0.5 | Hyper | 4 | 0.887 | 1.361 | 0.652 | No |
| RA | 65 | M | n | 0.5 | Hyper | 3 | 0.909 | 0.983 | 0.924 | No |
| RA | 66 | M | n | 0.5 | Hyper | 2 | 0.945 | 1.045 | 0.904 | No |
| RA | 46 | F | n | 0.5 | Hypo | 1 | 1.233 | 1.176 | 1.048 | No |
| RA | 62 | M | n | 0.5 | Normal | 4 | 1.171 | 1.153 | 1.015 | No |
| RA | 45 | F | n | 0.5 | Hyper | 3 | 1.078 | 1.118 | 0.964 | No |
| RCMD | 50 | F | −x | 1.0 | Hyper | 2 | 0.99 | 0.874 | 1.133 | No |
| RCMD | 49 | F | Complex | 1.5 | Hyper | 4 | 1.178 | 1.533 | 0.768 | Yes |
| RCMD | 33 | F | +8 | 1.0 | Normal | 3 | 1.011 | 1.01 | 1.001 | No |
| RCMD | 68 | F | n | 0.5 | Hyper | 1 | 0.923 | 0.92 | 1.003 | Yes |
| RCMD | 43 | F | n | 0.5 | Hypo | 3 | 1.555 | 0.856 | 1.816 | No |
| RCMD | 65 | F | Complex | 1.5 | Normal | 4 | 0.937 | 0.85 | 1.102 | Yes |
| RCMD | 60 | M | n | 0.5 | Normal | 3 | 0.952 | 0.946 | 1.006 | Yes |
| RARS | 48 | F | n | 0.5 | Normal | 4 | 0.96 | 0.825 | 1.163 | No |
| RARS | 48 | M | +5 | 1.0 | Normal | 4 | 1.015 | 0.801 | 1.267 | Yes |
| RARS | 56 | F | n | 0.5 | Hyper | 3 | 0.875 | 0.862 | 1.059 | No |
| RAEB-1 | 35 | M | Normal | 1.5 | Hyper | 9 | 0.957 | 0.904 | 1.02 | Yes |
| RAEB-1 | 56 | M | n | 1.0 | Hyper | 9 | 0.913 | 0.905 | 1.009 | Yes |
| RAEB-1 | 57 | M | Mono 7 | 1.5 | Hyper | 7 | 0.988 | 0.962 | 1.027 | No |
| RAEB-1 | 60 | M | n | 0.5 | Normal | 6 | 1.388 | 0.752 | 1.845 | No |
| RAEB-1 | 71 | M | Complex, −7 | 1.5 | Normal | 9 | 1.376 | 1.152 | 1.195 | Yes |
| RAEB-1 | 78 | M | +8 | 1.5 | Hyper | 6 | 0.929 | 0.882 | 1.054 | No |
| RAEB-1 | 71 | F | −7 | 1.5 | Hypo | 8 | 1.023 | 1.045 | 0.979 | No |
| RAEB-1 | 52 | F | 11q- | 1.5 | Hyper | 9 | 1.548 | 1.159 | 1.336 | No |
| RAEB-2 | 44 | F | 7q- | 2.5 | Hyper | 11 | 1.26 | 0.735 | 1.714 | No |
| RAEB-2 | 69 | F | n | 2.0 | Hyper | 18 | 0.997 | 1 | 0.997 | No |
| RAEB-2 | 69 | F | n | 2.0 | Hyper | 15 | 1.061 | 1.077 | 0.985 | No |
| RAEB-2 | 48 | M | n | 2.0 | Normal | 13 | 1.013 | 0.901 | 1.124 | No |
| RAEB-2 | 69 | M | +9 | 2.5 | Hyper | 19 | 1.3 | 0.686 | 1.895 | No |
| RAEB-2 | 48 | M | n | 2.0 | Normal | 13 | 1.013 | 0.901 | 1.124 | No |
| RAEB-2 | 56 | F | - 7 | 2.5 | Normal | 11 | 1.019 | 1.004 | 1.015 | Yes |
| RAEB-2 | 65 | M | Complex | 2.5 | Normal | 12 | 1.373 | 0.644 | 2.132 | Yes |
| RAEB-2 | 76 | F | t(6:9) | 2.0 | Hyper | 11 | 0.952 | 0.962 | 0.991 | No |
| RAEB-2 | 73 | F | 5q- | 2.0 | Hypo | 12 | 1.512 | 1.163 | 1.301 | No |
| RAEB-2 | 52 | M | 29 | 2.5 | Hyper | 12 | 1.023 | 0.793 | 1.289 | Yes |
| RAEB-2 | 57 | M | n | 2 | Normal | 15 | 1.011 | 0.925 | 1.094 | No |
| MDS sec | 56 | M | n | 2 | Hyper | 12 | 1.052 | 1.102 | 0.954 | No |
| MDS sec | 65 | M | n | 2 | Hyper | 15 | 1.077 | 0.769 | 1.4 | No |
| MDS sec | 58 | M | n | 2 | Hyper | 11 | 1 | 1.02 | 0.98 | No |
| MDS sec | 48 | M | Complex | 3 | Hyper | 11 | 1.2 | 1.864 | 0.644 | Yes |
| MDS sec | 62 | M | n | 2 | Hyper | 11 | 0.994 | 0.979 | 1.015 | No |
| MDS sec | 63 | F | n | 2 | Normal | 15 | 0.95 | 0.829 | 1.146 | No |
| MDS sec | 72 | F | Complex | 3 | Hyper | 19 | 1.139 | 1.093 | 1.043 | Yes |
| MDS sec | 48 | M | Complex | 3 | Hyper | 17 | 1.200 | 0.876 | 1.37 | No |
F indicates female; hyper/hypo, cellularity greater/lower than expected for age; IPSS, International Prognostic Scoring System; M, male; MDS, myelodysplastic syndrome; n, normal karyotype; outcome, 11 patients have died; RA, refractory anemia; RARS, RA with ringed sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; RAEB, RA with excess blasts (1 or 2); and sec, secondary (treatment-related) MDS or MDS after an antecedent hematologic disorder.