Table 1.
Characteristics of JMML patient cohort
| Variable | Total cohort, N = 49 |
|---|---|
| Median age at diagnosis, mo (range) | 32 (1-75) |
| Sex, male/female/unknown | 32/16/1 |
| NF1 by clinical diagnosis, yes/no | 2/47 |
| Median Hb, g/L (range) | 0.96 (0.49-1.20) |
| Median HbF, % (range) | 23.6 (1.0-62.0) |
| Median WBC, ×109/L (range) | 28.0 (10.9-126.2) |
| Median monocyte in PB count, ×109/L (range) | 4.5 (1.0-31.6) |
| Median plt, ×109/L (range) | 49 (1.4-320) |
| Metaphase cytogenetics, no. of patients (%) | |
| Normal karyotype | 35 (71.4) |
| Monosomy 7 | 8 (16.3) |
| Trisomy 8 | 1 (2.0) |
| Other abnormalities | 3 (6.1) |
| Unknown | 2 (4.1) |
| Hematopoietic stem cell transplantation | |
| Yes | 32 |
| No | 13 |
| Unknown | 4 |
| Status at last follow-up | |
| Alive | 24 |
| Dead | 21 |
| Unknown | 4 |
| Median observation period, mo (range) | 14 (1-216) |
NF1 indicates neurofibromatosis type1; Hb, hemoglobin; WBC, white blood cell; PB, peripheral blood; and plt, platelet.