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Functional assay of chimeric pRNA/siRNA targeting luciferase by transfection. (A) Dual reporter luciferase assay showing the specific knockdown of firefly luciferase or Renilla luciferase expression by pRNA/siRNA(firefly) or pRNA/siRNA(Renilla), respectively, in a dose-dependent manner. (B) Comparison of the activities of conventional hairpin siRNA(luciferase) and pRNA/siRNA(luciferase). pRNA/siRNA(mutant) with mutations in siRNA sequences was included as a nonspecific control.
