Table 1.

The shRNAs that consistently decreased BT474 cell proliferation in the RNAi screen

Symbol	Name	Function	% proliferation of control*	Z-score
ERBB2	V-erb-b2 erythroblastic leukemia viral oncogene homolog 2	Receptor Tyrosine Kinase	27.04	−2.86
MKI67	Antigen identified by monoclonal antibody Ki-67	Proliferation	32.99	−2.59
NR1D1	Nuclear receptor subfamily 1, group D, member 1	Adipogenesis - Fat metabolism	35.83	−2.46
PBP	PPAR binding protein PPARBP	Adipogenesis - Fat metabolism	37.08	−2.40
MAP2K6	Mitogen-activated protein kinase kinase 6	Adipogenesis - Signal Transduction	37.23	−2.39
SLPI	Secretory leukocyte protease inhibitor	Proteolysis	38.65	−2.33
PFN2	Profilin 2	Actin polymerization	41.06	−2.22
SPINT1	Serine protease inhibitor, Kunitz type 1	Proteolysis	42.87	−2.14
LASP1	LIM and SH3 protein 1	Actin cytoskeleton organization	43.27	−2.12
TPD52	Tumor protein D52	Secretion	46.50	−1.97
H2AFY	H2A histone family, member Y	Nucleosome assembly	50.46	−1.79
SIAT4C	Sialyltransferase 4C	Transferase activity	53.30	−1.66
SFRS7	Splicing factor, arginine/serine-rich 7, 35kDa	Splicing	53.87	−1.64
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	Apoptosis	54.62	−1.61
CA9	Carbonic anhydrase IX	Secretion	54.01	−1.61
RPL19	Ribosomal protein 19	Ribosome structure	55.23	−1.60
FADS2	Fatty acid desaturase 2	Fat metabolism	63.54	−1.20
STARD3	StAR-related lipid transfer (START) domain containing 3	Fat metabolism	66.88	−1.00
ERBB3	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3	Receptor Tyrosine Kinase	69.33	−0.94
GRB7	Growth factor receptor bound protein 7	Signal Transduction	71.41	−0.84
FASN	Fatty acid synthase	Fat metabolism	75.40	−0.66

^*Results shown are statistically significant (P<0.05). Dotted line indicates genes that produced close to or more than 50% decrease in proliferation