Figure 2. Pyramidal neuron model.

(A) Schematic representation of the two-compartment model and the ionic currents involved. The stimulus is injected into the dendritic compartment. Next to each compartment we also show an example trace of the membrane potential during burst generation. The ionic currents associated with each compartment are also indicated. See Methods for mathematical details. (B) Typical responses obtained for a random input current. The top trace represents a sample stochastic stimulus. The stimulus consists of a signal part (low-pass filtered Gaussian white- noise with 10 Hz cut-off frequency), and a noise component (low-pass filtered Gaussian white- noise with 1 KHz cut-off frequency, whose standard deviation (SD) is equal to ¼ of the SD of the signal). The four example traces correspond to the output of the neuron when stimulated with the same signal component, and four different realizations of the noise. The numbers on top of the traces indicate the number of spikes in the bursts.