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. 2010 Mar 12;6(3):e1000700. doi: 10.1371/journal.pcbi.1000700

Table 1. Summary of results clustered according to overall reaction similarity.

EC sub-subclass EC sub-subclass definition Domain combi-nations PDB-SprotEC Domain combinations dataset Pairs in dataset Pairs with similar overall reaction Pairs with similar mechanism Pairs with identical steps
Group 1: Sub-subclasses containing only highly similar and/or distantly similar overall reactions
1.3.99 Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors 2 2 1 1 0 0
1.5.1 Oxidoreductases; Acting on the CH-NH group of donors; With NAD+ or NADP+ as acceptor 9 2 1 1 0 0
2.2.1 Transferases; Transferring aldehyde or ketonic groups; Transketolases and transaldolases 2 2 1 1 0 0
2.3.3 Transferases; Acyltransferases; Acyl groups converted into alkyl groups on transfer 2 2 1 1 1 1
2.6.1 Transferases; Transferring nitrogenous groups; Transaminases 4 2 1 1 0 1
3.1.1 Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases 13 3 3 3 3 3
3.1.3 Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases 24 3 3 3 1 1
3.1.4 Hydrolases; Acting on ester bonds; Phosphoric-diester hydrolases 11 2 1 1 1 0
3.1.21 Hydrolases; Acting on ester bonds; Endodeoxyribonucleases producing 5′-phosphomonoesters 10 2 1 1 0 0
3.2.1 Hydrolases; Glycosylases; Glycosidases, i.e. hydrolysing O- and S-glycosyl compounds 21 2 1 1 1 0
3.5.1 Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides 12 4 6 6 2 1
3.5.2 Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amides 5 2 1 1 1 1
3.8.1 Hydrolases; Acting on halide bonds; In carbon-halide compounds 2 2 1 1 0 0
4.1.2 Lyases; Carbon-carbon lyases; Aldehyde-lyases 5 3 3 3 1 0
4.6.1 Lyases; Phosphorus-oxygen lyases; Phosphorus-oxygen lyases 4 2 1 1 0 0
5.1.1 Isomerases; Racemases and epimerases; Acting on amino acids and derivates 4 2 1 1 0 0
6.3.1 Ligases; Forming carbon-nitrogen bonds; Acid-ammonia (or amine) ligases (amide synthases) 3 2 1 1 1 1
Group 2: Sub-subclasses containing highly similar and/or distantly similar plus non-similar overall reactions
1.1.1 Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor 11 3 3 1 2 3
2.3.1 Transferases; Acyltransferases; Transferring groups other than aminoacyl groups 25 4 6 1 0 1
2.4.2 Transferases; Glycosyltransferases; Pentosyltransferases 15 6 15 3 2 4
4.1.1 Lyases; Carbon-carbon lyases; Carboxy-lyases 20 5 10 6 1 1
4.2.1 Lyases; Carbon-oxygen lyases; Hydro-lyases 24 7 21 3 1 3
Group 3: Sub-subclasses containing only non-similar overall reactions
2.1.1 Transferases; Transferring one-carbon groups; Methyltransferases 14 2 1 0 0 0
2.4.1 Transferases; Glycosyltransferases; Hexosyltransferases 4 2 1 0 0 0
3.2.2 Hydrolases; Glycosylases; Hydrolysing N-glycosyl compounds 6 2 1 0 1 0
3.5.4 Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines 8 2 1 0 0 0
4.2.3 Lyases; Carbon-oxygen lyases; Acting on phosphates 5 4 6 0 0 0
5.4.2 Isomerases; Intramolecular transferases; Phosphotransferases (phosphomutases) 5 2 1 0 0 0
5.4.99 Isomerases; Intramolecular transferases; Transferring other groups 6 2 1 0 0 0