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. Author manuscript; available in PMC: 2011 Feb 23.
Published in final edited form as: Circulation. 2010 Feb 8;121(7):906–915. doi: 10.1161/CIRCULATIONAHA.109.872903

Figure 3. Glucocorticoids suppress Th17-promoting cytokines and spare Th1-promoting cytokines in the circulation.

Figure 3

The proinflammatory cytokines IL-1β (A), IL-6 (B) and IL-12 (C) were measured in plasma samples of GCA patients before (No Tx) and after initiation of GC therapy (Tx) (n=6), and age-matched controls (Con) (n=6) by ELISArrays. Data are presented as absorbance values at 450nm. (D-H) CD14+ monocytes were purified from PBMC of GCA patients prior to steroid therapy (n=8) and after steroid therapy (n=8), or GCA negative donors (n=8). Transcripts of IL-1β (D), IL-6 (E), IL-23p19 (F), IL-12p40 (G) and IL-12p35 (H) in cell extracts were quantified by qRT-PCR.