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. 2009 Mar 20;131(14):5126–5133. doi: 10.1021/ja808064g

Figure 4.

Figure 4

Hyperopen conformations may accommodate nicked dsDNA binding. (A) Hyperopen conformation of the PBCV-1 mRNA capping enzyme. The centers of mass of the OB and nucleotidyltransferase domains are separated by 38.8 Å. Coloring is the same as in Figure 1. dsDNA was superimposed on the active site by aligning the nucleotidyltransferase domains of the capping enzyme and PBCV-1 DNA ligase. (B) PBCV-1 DNA ligase crystallized in complex with dsDNA. A unique “latch” domain is colored in green. The nucleotidyltransferase domain is shown in blue, the OB domain in red, and the hinge region in yellow.