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Lapatinib and 4-hydroxytamoxifen inhibit ER-mediated transcription activity in MCF7H cells. MCF7H cells and MCF7L cells were transfected with p2X ERE-Luc reporter plasmid for 36 h before treatment with DMSO (V), 1 μM 4OH-TAM (4OH), 5 μM Lapatinib or both drugs together in the absence or presence of 1 nM of E2 for an additional 12 h. Data are shown as means ± SE from three independent experiments. The value of ERE luciferase activity in vehicle-treated MCF7L cells is set as 1.
