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Reagents and conditions: a) 1.0 equiv 15, 15 equiv triethyl phosphite, 90 °C, 19 h, 98 %; b) 1.0 equiv 16, 1.0 equiv NaOMe, 1.0 equiv 6a, excess DMF, 25 °C, 24 h, 74 %; c) 1.0 equiv 17, 1.0 equiv nBuLi, 1.33 equiv DMF, THF, −78 °C, 60 %; d) 1.0 equiv 18, 1.1 equiv 7, 0.1 equiv piperidine, THF, 50 °C, 21 h, 97 %.
