Table 3. Predictors for event-free and overall survival using multivariate Cox regression analysis.

Covariate	HR	95% CI	P-value
Event-free survival
Patient gender
Female	Ref
Male	1.12	0.52–2.40	0.77
IELSG score
0–1 vs 2–3 vs 4–5 points	1.71	1.04–2.81	0.03
Treatment group
HD-MTX	Ref
HD-MTX/AraC	0.65	0.34–1.25	0.19
AUCHD-MTX
Per 100 μmol l−1 h increase	0.82	0.69–0.98	0.03
Overall survival
Patient gender
Female	Ref
Male	1.77	0.76–4.10	0.19
IELSG score
0–1 vs 2–3 vs 4–5 points	1.82	1.00–3.31	0.05
Treatment group
HD-MTX	Ref
HD-MTX/AraC	0.80	0.39–1.65	0.54
AUCHD-MTX
Per 100 μmol l−1 h increase	0.73	0.59–0.89	0.002

Abbreviations: HR=hazard ratio; CI=confidence interval; IELSG=International Extranodal Lymphoma Study Group; HD-MTX=high-dose methotrexate; HD-AraC=high-dose cytarabine; AUC=area under the curve; Ref=reference.