Table 1. The descriptive statistic of pedigrees.

	Populations		Large pedigrees		Extended pedigree
	Chaoshan	Taihang	Chaoshan	Taihang
individuals	7224	7379	62	158	293
affected	374	738	8	25	32
Male	268(71.66%)	458(62.06%)	5(62.5%)	16(64.0%)	17(53.13%)
Female	106(28.34%)	280(37.94%)	3(37.5%)	9(36.0%)	15(46.87%)
Mean of age-of-onset	60.75±11.32	61.65±10.11	49.25±8.59	59.78±11.05	51.68±9.90
Male	59.94±11.35	61.08±10.05	47.00±7.51	59.5±12.76	51.94±10.29
Female	62.78±11.03	62.53±10.18	53.00±10.58	60.28±7.61	51.40±9.79
pedigrees	224	403	2	4	1
One affected	134	228
Two affected	72	100
Three affected	12	32
More three affected	6	43	2	4	1