Table 4. Segregation analysis of oesophageal cancer in the Taihang general population with type influences age of onset and sex-dependence.
Parametera | Dominant | Recessive | Codominant | Descending | Polygenic | No major type | Environmental | General |
qA | 0.355 | 0.644 | 0.481 | 0.352 | 0.486 | - | 0.486 | 0.859 |
τAA | 1.0 | 1.0 | 1.0 | 1.0 | - | - | 0.486 | 0.49 |
τAB | 0.5 | 0.5 | 0.5 | 0.5 | - | - | 0.486 | 0.48 |
τBB | 0 | 0 | 0 | 0 | - | - | 0.486 | 0 |
βAAM | −12.729 | −12.729 | −13.194 | −12.729 | −14.827 | −10.770 | −14.827 | −12.980 |
βABM | −12.729 | −15.785 | −17.472 | −15.785 | −18.463 | −10.770 | −18.463 | −16.017 |
βBBM | −15.785 | −15.785 | −14.774 | −15.785 | −22.293 | −10.770 | −22.294 | −22.071 |
βAAF | −13.540 | −13.540 | −14.109 | −13.540 | −15.822 | −11.424 | −15.822 | −13.565 |
βABF | −13.540 | −16.596 | −18.387 | −16.596 | −19.458 | −11.424 | −19.458 | −16.602 |
βBBF | −16.596 | −16.596 | −15.689 | −16.596 | −23.288 | −11.424 | −23.289 | −22.656 |
α | 0.210 | 0.21 | 0.224 | 0.21 | 0.259 | 0.155 | 0.259 | 0.219 |
γ | 0b | 0 b | 0.100 | 0 b | 0.216 | 0.018 | 0.216 | 0.859 |
χ2 | 364.85 | 364.88 | 349.79 | 364.82 | 340.02 | 405.04 | 340.02 | |
df | 3 | 3 | 2 | 2 | 3 | 5 | 2 | |
P value | 9.07E-79 | 8.94E-79 | 1.11E-76 | 6.03E-80 | 2.16E-73 | 2.43E-85 | 1.46E-74 | |
-2lnL | 7907.39 | 7907.42 | 7892.33 | 7907.36 | 7882.56 | 7947.58 | 7882.56 | 7542.54 |
AIC | 7921.39 | 7921.42 | 7908.33 | 7923.36 | 7896.56 | 7957.58 | 7898.56 | 7562.54 |
-: Parameter at this value is not estimated.
a: See Materials and Methods for definitions of the parameters.
b: Parameter estimate went to bound.