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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jan 4;48(4):725–734. doi: 10.1016/j.yjmcc.2009.12.014

Figure 2. Transcriptomic and topological restructuring of the entry step in the glycolytic pathway: increase connection with mitochondria.

Figure 2

(A) A shift in hexokinase isoforms from Hxk-2 towards Hxk-1 and marginal reduction in enzyme activity in ES cell-derived cardiomyocytes (CM). Immunocytochemistry indicates that, compared to (B) ES cells, (C) cardiomyocytes have increased Hxk-1 abundance with a stippled pattern of intracellular localization and higher perinuclear concentration corresponding to mitochondrial network arrangement; the myofibrillar mesh is stained with α-actinin (red). Scale bar indicates 10 μm.