Fig 3.

Structures of representative N-acyl chain analogues of KRN7000. (A) Five examples are shown of glycolipids that induce Th2-biased iNKT cell responses. Although the structures vary widely, they all contain acyl chain modifications that introduce increased polarity such as unsaturations, chain truncation or incorporation of oxygen atoms. (B) An example of a highly active analogue in which the acyl chain is terminated by an aromatic ring. Such compounds have been reported to be potent iNKT cell activators and have been suggested to favor a more Th1-biased cytokine response. See text for references.