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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Immunol. 2009 Aug 10;183(5):3505–3511. doi: 10.4049/jimmunol.0901207

Figure 5. The NZM/NOD F1 mice develop high titers of ANA and anti-dsDNA antibodies.

Figure 5

Sera from mice (obtained at terminal time points) were screened for ANA titer by immunofluorescence (left panel). All F1 mice (n=21) were ANA positive with titers of 1:50 (n=3), 1:250 (n=8) and 1:1250 (n=10). NR means no reactivity detected at 1:50 dilution. The right panel shows reactivity of sera to dsDNA by ELISA. A mouse monoclonal anti-dsDNA antibody was used as a standard and results are expressed as anti-dsDNA antibody units. The solid lines indicate mean anti-dsDNA antibody units. Students t-Test was used to compare different groups and a p<0.05 considered statistically significant. Similar results were obtained in an additional experiment.