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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Structure. 2010 Mar 10;18(3):377–389. doi: 10.1016/j.str.2009.12.016

Figure 6. The stability of the dimer is more affected by mutations in the monomer zipper than by mutations in the dimer interface itself.

Figure 6

(A) Representative CD melting curves for wildtype Qua1 (blue), and the mutants E177A (dark green), Y149F (light green) and L173A (red). (B) The effect of Qua1 mutations on the melting temperature is mapped onto the crystal structure. (C) Y149 and E177 form a hydrogen bond that stabilizes the monomer helix-turn-helix fold, but is not part of the dimer interface.