Table 5.
Of the SNPs Listed in Table 4, the SNPs Associated with Tuberculosis in This Study Population
| RS number | Gene | Minor Allele Frequency | Average Testing Balanced Accuracy | Cross-validation Consistency | P-value |
|---|---|---|---|---|---|
| Any TB vs. PPD+, all patients | |||||
| Rs1811063 | TNF-α | 0.121 | 62.11# | 4/5 | 0.05 |
| Any TB vs. PPD+, black patients | |||||
| Rs1399431 Rs7791836 |
TLR4 TNF-α |
0.401 0.5 |
71.27^ | 3/5 | 0.02 |
#Testing Sensitivity: 0.55; Testing Specificity: 0.69
^ Testing Sensitivity: 0.71; Testing Specificity: 0.72. In post-hoc logistic regression analysis using these 2 SNPs, a recessive encoding for each SNP maximized the model fit.
The above are Multifactor Dimensionality Reduction models. Only models with P ≤ 0.05 are presented here.