Table 1.
Cases (n = 10) |
Control 1a (n = 17) |
Control 2b (n = 35) |
|
---|---|---|---|
Median Age, years (Range) | 35 (9 - 89) | 43 (19 - 75) | 63 (28 - 81) |
Male gender (%) | 8 (80.0) | 13 (76.5) | 24 (68.6) |
Allogenic stem-cell transplantation (%) | 2 (20.0) | 8 (47.1) | 0 (0.0) |
Neutropenia (%) c | 9 (90.0) | 11 (64.7) | 0 (0.0) |
Serum galactomannan testing: | |||
- Number tested (%) | 10 (100.0) | 11 (64.7) | 1 (2.9) |
- Median OD index (range)d | 0.3 (0.1 - 1.8) | 0.1 (0.0 - 0.2) | 0.2 |
BAL galactomannan testing: | |||
- Median OD index (range) | 4.1 (1.1 - 7.7) | 0.2 (0.1 - 1.0) | 0.4 (0.1 - 1.1) |
- OD index ≥ 0.5 (%) | 10 (100) | 3 (17.6) | 11 (31.4) |
BAL fungal cultures (%): | 10 (100) | 17 (100) | 18 (51.4) |
- Candida spp. (%) | 1 (10.0) | 6 (35.3) | 6 (33.3) |
- Aspergillus spp. (%) | 1 (10.0) | 0 (0.0) | 0 (0.0) |
Primary pulmonary diagnoses: | |||
- IPA (%) | 10 (100.0) | 0 (0.0) | 0 (0.0) |
- Bacterial pneumonia (%) | 0 (0.0) | 4 (23.5) | 14 (40.0) |
- Lung cancer (%) | 0 (0.0) | 0 (0.0) | 12 (34.3) |
- Graft vs. host disease (%) | 0 (0.0) | 5 (29.4) | 0 (0.0) |
- Viral pneumonitis (%) | 0 (0.0) | 2 (11.8) | 0 (0.0) |
- Interstitial lung disease (%) | 0 (0.0) | 0 (0.0) | 3 (8.6) |
- Others (%) | 0 (0.0) | 6 (35.3) | 6 (17.1) |
a Controls with underlying hematological diseases meeting EORTC/MSG host factors criteria for invasive fungal disease [3].
b Controls with no underlying hematological diseases.
c Absolute neutrophil count < 500/mm3
d Highest serum galactomannan OD index within two weeks of bronchoscopy, if test was performed.