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Pathological findings in the right frontal lobe of case 1 reveal severe spongiform changes and neuronal loss. However, astrocytic gliosis, accumulation of PrPSc, and microglial activation are less apparent in the cerebral cortex. a HE staining. b CD68 staining. c S100b protein staining (× 10). d S100b protein staining (× 200).
