TABLE III.

Subject demographics and medication use

	Mild (n = 164)	Moderate (n = 70)	Severe (n = 204)	P value
Demographics
Current age (y)	31 ± 12	38 ± 12	41 ± 13	<.00001‡
Age of asthma onset (y)	15 ± 13	18 ± 15	16 ± 16	.37
Asthma duration (y)	17 ± 11	20 ± 14	25 ± 14	<.0001*
Sex (% female)	72%	56%	64%	.05
Race (% white/African American/other)	69/25/6	66/29/5	67/26/7	.92
Asthma medications
ICSs‖	58%	100%	98%	<.0001‡
OCSs‖	0%	0%	32%	ND
LABAs§	48%	80%	89%	.001*
Leukotriene modifiers	22%	26%	51%	<.0001†
Omalizumab	0.1%	0%	12%	<.0001†
Theophyllines	0%	4%	18%	<.0001*
Anticholinergic agents	4%	6%	20%	<.0001†

ND, Not determined.

^*Three-way comparison significant; all groups are different.

^†Three-way comparison, significant because of differences between severe vs mild and moderate.

^‡Three-way comparison, significant because of differences between mild vs moderate and severe.

^§No subjects were on LABA monotherapy.

^‖ICS/OCS use was part of the definition of disease severity.