TABLE V.
Clinical characteristics of severe asthma based on age of asthma onset
Onset < 12 years (n = 100) | Onset ≥12 years (n = 104) | P value | |
---|---|---|---|
Current age (y) | 34 ± 13 | 48 ± 10 | <.0001 |
Asthma duration (y) | 32 ± 13 | 19 ± 11 | <.0001 |
Sex (% female) | 60% | 68% | .24 |
Race (% white/African American/other) | 61/30/9 | 72/21/7 | .25 |
Baseline lung function | |||
FEV1 % predicted | 64 ± 21 | 59 ± 21 | .63 |
FVC % predicted | 81 ± 21 | 73 ± 19 | .004 |
FEV1/FVC % | .65 ± .14 | .64 ± .13 | .50 |
Maximal % change in FEV1 | 20 ± 20 | 21 ± 27 | .77 |
FeNO (ppb) | 38 ± 35 | 41 ± 41 | .69 |
Blood eosinophils (log) | −.75 ± .47 | −.76 ± .54 | .84 |
Total serum IgE (log) | 2.2 ± .69 | 1.9 ± .79 | .19 |