Figure 2.
Intrinsic membrane properties associated with theta fluctuations in medial entorhinal cortical stellate cells require channel noise. Reproducing subthreshold theta oscillations in stellate cells in the presence of riluzole (INaP blocker) requires a noisy representation of INaP. Raw traces of subthreshold membrane voltage (A), power spectral density (PSD) plot (B), and power in the theta band (C, <σ2Vθ>, value defined as the integral of the PSD within the theta range-dotted lines) of subthreshold membrane voltage was more closely matched to control when a stochastic differential equation (SDE) was used to implement the INaP in the presence of riluzole. Implementation of a deterministic model of INaP using a standard ordinary differential equation (ODE) fails to reproduce control levels of power at theta in membrane voltage fluctuations (B, C). Asterisk denotes significance using a pairwise t test. Adapted with permission from Dorval and White (2005). Ctrl, Control.