Onset of melatonin secretion is much earlier in degus than in rats. Melatonin secretion was monitored in degus (red dots, n = 3), Sprague Dawley (SD) rats (purple dots, n = 5), and Wistar rats (green dots, n = 8) using pineal microdialysis, and normalized to daily maximum levels. The dashed line represents 20% of the maximum levels. Animals were housed in LD12:12 hr with lights-off at 18:00 hr. Compared with rats, degus clearly display advanced onset of melatonin secretion.