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. Author manuscript; available in PMC: 2010 Aug 18.
Published in final edited form as: Oncogene. 2009 Nov 2;29(7):949–956. doi: 10.1038/onc.2009.376

Figure 4. Impaired G2-M checkpoint and ATM activation in R175H mutant cells after irradiation.

Figure 4

G2-M checkpoint in MEFs (a) and proliferating thymocytes (b) of various genotypes. Mean values from three independent experiments are shown with standard deviation. P values between p53−/− and other samples are indicated. (c) IRIF of ATM-1981p in p53−/− and R175H MEFs 30 mins after 2Gy irradiation. Nucleus is countered stained with DEPI. (d) Phosphorylation of H2AX (γ-H2AX) in p53−/− and R175H mutant MEFs after 2Gy of IR.