TABLE 3.
Positive rates of antibody responses to M. tuberculosis antigens
| Group and status | No. of subjects | Positive rate of antibody response to M. tuberculosis antigen (95% CI) |
|||||
|---|---|---|---|---|---|---|---|
| Single antigen |
Combinations of antigens |
||||||
| r38kDa | rMTB48 | rCFP-10/ESAT-6 | r38kD and rMTB48 | r38kD and rCFP-10/ESAT-6 | r38kD, rMTB48, and rCFP-10/ESAT-6 | ||
| Healthy controls | |||||||
| PPD− | 129 | 16.3 (10.4-23.8) | 16.3 (10.4-23.8) | 7.8 (3.8-13.8) | 28.7 (21.1-37.3) | 22.5 (15.6-30.7) | 34.1 (26.0-43.0) |
| PPD+ | 131 | 26.7b (19.4-35.2) | 36.6b (27.7-44.7) | 20.6b (14.0-28.6) | 44.3b (35.6-53.2) | 34.4b (26.3-43.2) | 49.6b (40.8-58.5) |
| Total | 260 | 21.5 (16.6-27.0) | 26.2 (20.9-31.9) | 14.2 (10.2-19.1) | 36.5 (30.7-42.7) | 28.5 (23.1-34.4) | 41.9 (35.9-48.2) |
| TB patients | |||||||
| Bacterium− | 131 | 73.3 (64.9-80.6) | 72.5 (64.0-80.0) | 55.0 (46.0-63.4) | 83.2 (75.7-89.2) | 77.1 (69.0-84.0) | 84.7 (77.4-90.4) |
| Bacterium+ | 119 | 73.9 (65.1-81.6) | 73.9 (65.1-81.6) | 66.4 (57.2-74.8) | 84.9 (77.2-90.8) | 86.6 (79.1-92.1) | 90.8 (84.1-95.3) |
| Total | 250 | 73.6c (67.7-79.0) | 73.2c (67.3-78.6) | 60.4c (54.0-66.5) | 84.0c (78.9-88.3) | 81.6c (76.2-86.2) | 87.6c (82.9-91.42) |
a
r38kD, recombinant 38-kDa antigen.
b
P < 0.05 versus PPD− controls determined by χ2 test.
c
P < 0.001 versus healthy controls determined by χ2 test.