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Model of the hdrRM-regulated competence pathway. HdrM (M) responds to unknown environmental signals which regulate the antagonism of HdrR (R) transcription factor activity. When the environmental conditions are such that HdrM is unable to antagonize HdrR, this will allow HdrR to activate the transcription of comX for natural competence and nlmA for mutacin IV production. This pathway functions in parallel with ComD (D) and ComE (E), which respond to the presence of CSP.
