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A model of the BAF250-containing E3 ubiquitin ligase. (A) VHL is a substrate adapter associated with the Elo B/C-Cul2-Roc1 complex, which ubiquitinates HIF1α. (B) BAF250 forms an E3 ubiquitin ligase with Elo B/C, Cul2, and Roc1 that targets histone H2B.
