TABLE 2.
Selected genes whose expression was altered in the repeated-stimulation and priming models
| Gene | Description or alternate designation | Function(s) of protein |
|---|---|---|
| Genes upregulated in the repeated-stimulation model | ||
| ARRB1 | Arrestin beta 1 gene | Scaffold, activates ERK1/2 |
| CDC42 eff 5 | ||
| CCL8 | MCP2 | |
| CCL26 | Eotaxin 3 gene | |
| CCL27 | CTACK | |
| IL17RD | Sef | Receptor for IL-17D; also functions as an ERK1/2 scaffold in the Golgi apparatus |
| MAP3K10 | Mixed-lineage kinase 2 (MLK2) gene | |
| MAP3K11 | Mixed-lineage kinase 3 (MLK3) gene | |
| MAP4K1 | HPK1 | |
| MAPK8IP1 | JNK-interacting protein 1 (JIP1) gene | |
| MAP2K2 | MAP ERK kinase 2 (MEK2) gene | Activates ERK1/2 |
| MKNK1 | Mnk1 | Cap-dependent protein translation |
| MUC5 | Mucin gene | |
| PFKFB4 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 gene | Aerobic glycolysis, cell proliferation |
| RAB4B | Rab4b | Early endosome-associated GTPase |
| SPRY4 | Sprouty 4 gene | Development/regulation of signaling |
| UNC119 | HRG4 | Activates Src kinases |
| Genes downregulated in the repeated-stimulation model | ||
| BIM | Proapoptotic molecule | |
| CBL | Cbl | Receptor-associated ubiquitin ligase, degrades Sprouty |
| DUSP4 | Dual-specific phosphatase gene | Dephosphorylates nuclear ERK1/2 |
| IL13RA1 | IL-13 receptor alpha 1 gene | |
| PFKFB2 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 gene | Aerobic glycolysis, cell proliferation |
| Genes upregulated in the priming model | ||
| CDYL | Chromodomain protein Y-like gene | Chromatin assembly/disassembly |
| CHMP4A | Chromatin-modifying protein 4A gene | |
| CLCA1 | Calcium-activated chloride channel regulating mucus | |
| EGFR | EGF receptor gene | |
| EGR1 | Early growth response 1 gene | Regulation of transcription |
| EMP3 | Epithelial membrane protein 3 gene | Negative regulation of proliferation |
| ETV5 | ets variant gene 5 | Regulation of transcription |
| FOS | Transcription | |
| GPATCH1 | Gpatch domain containing 1 gene | Intracellular; nucleic acid binding |
| JAG1 | jagged 1 | Cell fate determination/morphogenesis of epithelial sheet |
| JMJD6 | Jumonji domain containing 6 gene | Development/differentiation |
| PLK3 | polo-like kinase 3 gene | Regulation of cell cycle |
| RAB5B | Early endosome-associated GTPase | |
| SERTAD1 | serta domain containing 1 gene | Regulation of cyclin protein kinase |
| ZNF264 | Regulation of transcription |