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Origin of human enterovirus 71 (EV-71). (A) Phylogenetic relationships of EV-71 genogroups with coxsackievirus A16. Coxsackievirus A16 sequences shown in the cladogram were previously reported by Perera et al. (56). (B) The date of the MRCA of EV-71 was estimated to be 1941.0 (95% CR, 1928.8 to 1952.2) using a relaxed molecular clock and an exponential population growth model (22), as implemented in BEAST (24).
