TABLE 1.
Evolutionary characteristics of EV-71 genogroups B and C and their respective subgenogroups based on the VP1 gene
| EV-71 genogroup and subgenogroup | Year first isolated (country) | Divergence according to the indicated evolutionary modela |
|||
|---|---|---|---|---|---|
| Exponential growth (GTR+γ4) |
Constant size (GTR+γ4) |
||||
| Substitution rate (CR)b | Time of emergence (yr [CR]) | Substitution rate (CR)b | Time of emergence (yr [CR]) | ||
| Genogroup B | 4.5 (4.3-4.7) | 4.6 (4.4-4.8) | |||
| B1 | 1972 (United States) | 1966.8 (1964.7-1968.8) | 1967.0 (1964.9-1968.9) | ||
| B2 | 1981 (United States) | 1978.8 (1977.9-1979.8) | 1978.9 (1977.9-1979.8) | ||
| B3 | 1997 (Malaysia) | 1994.8 (1993.9-1995.7) | 1994.7 (1993.6-1995.5) | ||
| B4 | 1997 (Malaysia) | 1993.2 (1991.8-1994.6) | 1993.2 (1991.7-1994.6) | ||
| B5 | 2003 (Japan) | 2001.2 (2000.6-2001.8) | 2001.2 (2000.6-2001.8) | ||
| Genogroup C | 4.2 (4.0-4.4) | 4.2 (4.0-4.4) | |||
| C1 | 1986 (Australia) | 1983.3 (1982.3-1984.2) | 1983.3 (1982.2-1984.2) | ||
| C2 | 1995 (Australia) | 1992.9 (1991.5-1994.0) | 1992.7 (1991.3-1993.9) | ||
| C3 | 2000 (Korea) | 1998.8 (1998.2-1999.4) | 1998.8 (1998.1-1999.2) | ||
| C4 | 1998 (Taiwan) | 1992.8 (1991.0-1994.5) | 1992.8 (1991.0-1994.6) | ||
| C5 | 2005 (Vietnam) | 2002.8 (2001.9-2003.6) | 2002.7 (2001.8-2003.6) | ||
a
Based on relaxed (uncorrelated lognormal) coalescent inference. The 95% highest posterior density CRs are given in parentheses. See Materials and Methods for further details of the estimation procedure.
b
Substitution rates are expressed as 10−3 substitutions per site per year.