Fig 5.
Developmental profile of CYP1A inducibility by 6-formylindolo[3,2-b]carbazole (FICZ) in zebrafish embryos, larvae, and juveniles. Zebrafish at different developmental stages (6 hpf, or 1, 2, 3, 4, 7, 14 or 28 dpf) were exposed to FICZ (10 nM) or DMSO for 6 hours. CYP1A induction A) versus the matching control (EΔCt[sample]/mean EΔCt[control]) and B) versus the 12-hour control (EΔCt[sample]/mean EΔCt[12-h control]). Statistically significant differences between groups (n=5) were determined by one-way ANOVA followed by Tukey’s post hoc test and are shown by different letters (p < 0.05).