Table 1.
Demographics, including Z scores
| Total (N=217) | Dropouts (N=27) | Completers (N=190) | p-value | |
|---|---|---|---|---|
| White race, n (%) (n=217) | 198 (91.2%) | 25 (92.6%) | 173 (91.1%) | 1.00 |
| Sex, male, n (%) (n=217) | 96 (44.2%) | 13 (48.2%) | 83 (43.7%) | 0.68 |
| Late age of onset (≥ age 60), n (%) (n=199) | 90 (45.2%) | 7 (38.9%) | 83 (45.9%) | 0.63 |
| Age, mean (SD) (n=217) | 68.4 (7.2) | 67.8 (6.3) | 68.6 (7.3) | 0.79 |
| Age of onset, mean (SD) (n=199) | 53.6 (17.2) | 53.4 (15.7) | 53.6 (17.3) | 0.86 |
| Education, mean (SD) (n=217) | 14.2 (3.1) | 13.2 (3.1) | 14.4 (3.1) | 0.09 |
| MMSE, mean (SD) (n=216) | 27.7 (2.0) | 27.4 (2.3) | 27.8 (2.0) | 0.43 |
| VRF, mean (SD) (n=211) | 11.7 (4.6) | 11.6 (4.6) | 11.7 (4.6) | 0.96 |
| Baseline MADRS, mean (SD) (n=217) | 26.0 (4.4) | 25.1 (4.5) | 26.1 (4.4) | 0.25 |
| Episodic Memory, mean (SD) (n=198) | -0.34 (3.1) | -0.03 (2.8) | -0.37 (3.2) | 0.66 |
| Language Processing, mean (SD) (n=193) | -0.10 (2.3) | 0.12 (2.2) | -0.12 (2.4) | 0.45 |
| Working Memory, mean (SD) (n=197) | -0.04 (2.3) | -0.74 (2.1) | 0.03 (2.3) | 0.10 |
| Processing Speed, mean (SD) (n=192) | 0.004 (2.5) | 0.54 (2.3) | -0.05 (2.6) | 0.31 |
| Executive Function, mean (SD) (n=184) | -0.10 (3.3) | 0.12 (3.2) | -0.12 (3.4) | 0.80 |
| Total Fazekas Score, mean (SD) (n=184) | 4.2 (2.4) | 4.5 (2.5) | 4.2 (2.3) | 0.56 |
| Total Fazekas Categorical (Fazekas Total>2), n (%) (n=184) | 127 (69.0%) | 8 (80.0%) | 119 (68.4%) | 0.73 |
| Last Sertraline Dose (mg), mean (SD) (n=204) | 114.0 (54.2) | 72.2 (38.2) | 118.0 (53.9) | 0.0007 |
Note: Fisher's exact test for categorical variables and Wilcoxon Rank-Sum test for continuous variables