Figure 4.
Characteristics of selected Class II peptides. The peptide IDs and amino acid sequences are shown followed by their gene expression temporality. Here “early and late” refers to early and late post-replication phase expression. The accession numbers for the corresponding ORFs within 3 variola and 4 vaccinia genomes are listed. The top 25 epitopes were discovered in the first Class II epitope screen and the bottom 25 in the second (see Results). In addition, the EpiMatrix Class II cluster score, the cluster sum of DRB1*0101 scores and % inhibition of competitor peptide binding to DRB1*0101 at 100 μM epitope peptide are shown. Asterisks refer to peptides that were not assayed for binding.