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. 2010 Jan 15;285(12):8543–8551. doi: 10.1074/jbc.M109.045906

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Purified exosomes containing ULBP3 are potent modulators of NK cell NKG2D-mediated cytotoxicity. A, primary NK cells recognize CHO-MICA transfectants in an NKG2D-dependent fashion. B, effect of purified exosomes on NK cell cytotoxicity against CHO-MICA and untransfected CHO. Purified exosomes from either untransfected or ULBP3-transfected CHO cells (40–100 ng total protein) were incubated with primary NK cells for 24 h. After preincubation with exosomes, NK cells were used as effectors in a cytotoxicity assay (measured using a fluorimetric assay). E:T, effector:target ratio.