FIGURE 8.

Decylubiquinone increases complex II/III inhibition threshold in synaptosomes. Rat brain synaptosomes were incubated with a series of concentrations of myxothiazol (0–1 μm) in the absence and presence of 50 μm decylubiquinone in Krebs buffer in an oxygen electrode at 37 °C. Rates of oxygen consumption and corresponding complex II/III activity were determined and expressed as percentages of their controls and used to generate the complex II/III inhibition threshold curves in the absence (●) and presence (○) of decylubiquinone. The control rates of complex II/III activity in the absence and presence of decylubiquinone were 33.9 ± 2.5 nmol/min/mg and 64.4 ± 5.8 nmol/min/mg, respectively. Experiments were performed on five individual preparations, and results are expressed as mean ± S.E. (error bars).