FIGURE 2.

Lipid IV_A packs tilted and shallowly in the mouse MD-2 hydrophobic pocket in the docked mMD-2·lipid IV_A complex. The docked mMD-2·lipid IV_A complex is shown in two perpendicular views in a and overlaid to the hMD-2·lipid IV_A co-crystal structure in b. MD-2 is shown in ribbon views in a and b, and lipid IV_A is shown in sphere view in a and stick view in b. The residues interacting with lipid IV_A are colored red, and the β4 strand is colored blue in a. The fourth acyl chain of lipid IV_A is labeled L4 in both a and b. Green, mMD-2; yellow, lipid IV_A in mMD-2; pink, hMD-2; cyan, lipid IV_A in hMD-2. The graphics were created using PyMol (DeLano Scientific).