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Colocalization of PrP-128M and PrP-128V aggregates in the yeast cytosol. Differential interference contrast (DIC) (far left) and fluorescence images of yeast after 16 h of co-expression of PrP-128M and PrP-128V fluorophore pairs tagged with either CFP or YFP, as labeled. The far right column displays merged images. Both PrP fusion proteins produce dense aggregates. Co-expression of homologous or heterologous pairs produce >90% co-aggregation.
