TABLE 4.

Voltage dependence of activation and inactivation for Na_v 1.3 III-IV mutants

Values presented are means ± S.D.

Channel	Voltage dependence
	Inactivation			Activation
	V½	a	n	V½	z	n
	mV	mV		mV	e0
Nav1.3	−16.2 ± 0.8	4.7 ± 0.5	8	−14.6 ± 2.4	6.9 ± 0.6	8
K1441Q/K1442Q	−24.4 ± 1.1a	5.8 ± 0.5b	9	−12.9 ± 1.8	6.4 ± 0.5	6
K1453Q	−27.8 ± 2.2c	6.6 ± 1.0b	5	−18.9 ± 1.6b	7.2 ± 1.2	8
K1454Q	−20.9 ± 1.0c	4.6 ± 0.4	7	−15.9 ± 1.8	7.2 ± 1.0	5
K1457Q	−22.2 ± 0.8c	4.8 ± 0.5	5	−15.6 ± 1.8	7.3 ± 0.6	3
K1465Q	−18.2 ± 1.0d	4.9 ± 0.5	8	−14.6 ± 2.2	6.9 ± 0.6	8
K1453E	−36.4 ± 0.8a	7.4 ± 0.3a	10	−12.8 ± 1.5	6.4 ± 0.4	9
K1453Q/K1826E	−37.3 ± 1.2a	7.7 ± 0.8c	6	−17.9 ± 2.4	8.0 ± 1.2	5
K1453E/K1826E	−33.0 ± 2.1a	7.1 ± 1.4†	7	−14.6 ± 1.4	6.8 ± 0.4	3
K1453D/K1826E	−29.2 ± 1.9a	6.8 ± 1.0†	17	−10.8 ± 1.3	7.2 ± 0.6	6

^a Significantly different from Na_v1.3, p < 0.000000001.

^b Significantly different from Na_v1.3, p < 0.001.

^c Significantly different from Na_v1.3, p < 0.0000005.

^d Significantly different from Na_v1.3, p < 0.005.