TABLE 4.
Channel | Voltage dependence |
|||||
---|---|---|---|---|---|---|
Inactivation |
Activation |
|||||
V½ | a | n | V½ | z | n | |
mV | mV | mV | e0 | |||
Nav1.3 | −16.2 ± 0.8 | 4.7 ± 0.5 | 8 | −14.6 ± 2.4 | 6.9 ± 0.6 | 8 |
K1441Q/K1442Q | −24.4 ± 1.1a | 5.8 ± 0.5b | 9 | −12.9 ± 1.8 | 6.4 ± 0.5 | 6 |
K1453Q | −27.8 ± 2.2c | 6.6 ± 1.0b | 5 | −18.9 ± 1.6b | 7.2 ± 1.2 | 8 |
K1454Q | −20.9 ± 1.0c | 4.6 ± 0.4 | 7 | −15.9 ± 1.8 | 7.2 ± 1.0 | 5 |
K1457Q | −22.2 ± 0.8c | 4.8 ± 0.5 | 5 | −15.6 ± 1.8 | 7.3 ± 0.6 | 3 |
K1465Q | −18.2 ± 1.0d | 4.9 ± 0.5 | 8 | −14.6 ± 2.2 | 6.9 ± 0.6 | 8 |
K1453E | −36.4 ± 0.8a | 7.4 ± 0.3a | 10 | −12.8 ± 1.5 | 6.4 ± 0.4 | 9 |
K1453Q/K1826E | −37.3 ± 1.2a | 7.7 ± 0.8c | 6 | −17.9 ± 2.4 | 8.0 ± 1.2 | 5 |
K1453E/K1826E | −33.0 ± 2.1a | 7.1 ± 1.4† | 7 | −14.6 ± 1.4 | 6.8 ± 0.4 | 3 |
K1453D/K1826E | −29.2 ± 1.9a | 6.8 ± 1.0† | 17 | −10.8 ± 1.3 | 7.2 ± 0.6 | 6 |
a Significantly different from Nav1.3, p < 0.000000001.
b Significantly different from Nav1.3, p < 0.001.
c Significantly different from Nav1.3, p < 0.0000005.
d Significantly different from Nav1.3, p < 0.005.