Table 3.
Effect of body mass index on prostate cancer risk and survival, according to endostatin D104N genotype, Physicians’ Health Study 1982-2007
| Relative risk (95% CI) | |||
|---|---|---|---|
| NN/DN genotype |
DD genotype | P for interaction |
|
| Prostate Cancer Risk 1 | |||
| Overweight/Obese | 0.9 (0.5-1.5) | 1.6 (1.2-2.1) | <0.001 |
| Healthy weight | 1.8 (1.2-2.6) | REF | |
|
| |||
| Prostate Cancer Survival 2 | |||
| Overweight/Obese | 1.2 (0.5-3.0) | 1.7 (1.2-2.5) | 0.08 |
| Healthy weight | 1.7 (1.0-2.9) | REF | |
1
Relative risk from unconditional logistic regression models, adjusted for matching factors age, smoking status, and follow-up time
2
Hazard ratios (95% Confidence Intervals) from Cox proportional hazard models among cases only, adjusted for age at diagnosis, tumor grade and stage